Selected Publications

  1. Toshiaki Nakashiba, Jesse D. Cushman, Kenneth A. Pelkey, Sophie Renaudineau, Derek L. Buhl, Thomas J. McHugh, Vanessa Rodriguez Barrera, Ramesh Chittajallu, Keisuke S. Iwamoto, Chris J. McBain, Michael S. Fanselow and Susumu Tonegawa. Young Dentate Granule Cells Mediate Pattern Separation whereas Old Granule Cells Facilitate Pattern Completion. Cell. in press (2012).
  2. Suh J, Rivest AJ, Nakashiba T, Tominaga T, Tonegawa S. Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory. Science 334: 1415-2 (2011).
  3. Govindarajan, A., Israely, I., Huang, S.Y., and Tonegawa, S. The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP. Neuron 69:132-146 (2011). (SOM)
  4. Dragoi, G. and Tonegawa, S. Preplay of future place cell sequences by hippocampal cellular assemblies. Nature 469: 397-403 (2011). (SOM)
  5. Slutsky, I., Abumaria, N., Wu, L., Huang, C., Zhang, L., Li, B., Zhao, X., Govindarajan, A., Zhao, M., Zhuo, M., Tonegawa, S., and Liu, G. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron 65:165-177 (2010). (SOM)
  6. Jinde, S., Belforte, J.E., Yamamoto, J., Wilson, M.A., Tonegawa, S., and Nakazawa, K. Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death. European Journal of Neuroscience 30:1036–1055 (2009). (SOM)
  7. Nakashiba, T., Buhl, D.L., McHugh, T.J., and Tonegawa, S. Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory. Neuron 62:781-787 (2009). (SOM)
  8. Nakashiba, T., Young, J.Z., McHugh, T.J., Buhl, D.L., and Tonegawa, S. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science 319:1260-1264 (2008). (SOM)
  9. Tonegawa, S., and McHugh, T.J. The ins and outs of hippocampal circuits. Neuron 57: 175-177 (2008).
  10. Hayashi, M.L.,Shankaranarayana Rao, B.S., Seo, J.S., Choi, H.S., Dolan, B.M., Choi, S.Y., Chattarji, S., and Tonegawa, S. Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. PNAS 104:11489-11494 (2007). (SOM)
  11. McHugh, T.J., Jones, M.W., Quinn, J.J., Balthasar, N., Coppari, R., Elmquist, J.K., Lowell, B.B., Fanselow, M.S., Wilson, M.A., and Tonegawa, S. Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network. Science 317:94-99 (2007). (SOM)
  12. Govindarajan, A., Shankarananarayana Rao, B.S., Nair, D., Trinh, M., Mawjee, N., Tonegawa, S., and Chattarji, S. Transgenic brain-derived neuroptrophic factor expression causes both anxiogenic and antidepressant effects. PNAS 103:13208-13213 (2006). (SOM)
  13. Govindarajan, A., Kelleher, R.J., and Tonegawa, S. A clustered plasticity model of long-term memory engrams. Nature Reviews Neuroscience 7:575-583 (2006).
  14. Kelleher, R.J., Govindarajan, A., Jung, H.-Y., Kang, H., and Tonegawa, S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116:467-479 (2004).
  15. Gerber, D.J., Hall, D., Miyakawa, T., Demars, S., Gogos, J.A., Karayiorgou, M., and Tonegawa, S. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. PNAS 100:8993-8998 (2003).
  16. Miyakawa, T., Leiter, L.M., Gerber, D.J., Gainetdinov, R.R., Sotnikova, T.D., Zeng, H., Caron, M.G., and Tonegawa, S. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. PNAS 100:8987-8992 (2003).
  17. Nakazawa, K., Quirk, M.C., Chitwood, R.A., Watanabe, M., Yeckel, M.F., Sun, L.D., Kato, A., Carr, C.A., Johnston, D., Wilson, M.A., and Tonegawa, S. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297:211-218 (2002).
  18. Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B.D., Miyakawa, T., Bear, M.F., and Tonegawa, S. Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory. Cell 107:617-629 (2001).
  19. McHugh, T.J., Blum, K.I., Tsien, J.Z., Tonegawa, S., and Wilson, M.A. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87:1339-1349. (1996).
  20. Tsien, J.Z., Huerta, P.T., and Tonegawa, S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87:1327-1338 (1996).
  21. Tsien, J.Z., Chen, D.F., Gerber, D., Tom, C., Mercer, E.H., Anderson, D.J., Mayford, M., Kandel, E.R., and Tonegawa, S. Subregion-and cell type-restricted gene knockout in mouse brain. Cell 87:1317-1326 (1996).
  22. Silva, A., Stevens, C., Tonegawa, S., and Wang, Y. Deficient Hippocampal Long-Term Potentiation in a Calcium-Calmodulin Kinase II Mutant Mice. Science 257:201-206 (1992).
  23. Silva, A., Paylor, R., Wehner, J.M., and Tonegawa, S. Impaired Spatial Learning in a Calcium-Calmodulin Kinase II Mutant Mice. Science 257:206-211 (1992).
  24. Tonegawa, S. The Molecules of the Immune System. Scientific American 253:122-131 (1985).
  25. Tonegawa, S. Somatic Generation of Antibody Diversity. Nature 302:575-581 (1983).

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